Chemotherapy treatment effects on tooth development: narrative review
Keywords:
Chemotherapy, Odontogenesis, Cancer survivors, Tooth AbnormalitiesAbstract
The malignant tumors diagnosed in children aged between zero and fifteen years has its therapy administered during the age of tooth formation, which may interfere with this development, especially with regard to the formation of permanent teeth. Objectives: to analyze, through a literature review, the effects of chemotherapy on dental development. Methods: data sources encompassed two databases. Clinical observation studies of groups of patients whose chemotherapy treatment was performed in childhood (between 0 and 15 years old) were included. Nine articles were selected. Results: Enamel deformities and root malformations were the most commonly found alterations as a result of chemotherapy treatment. There is no consensus on the relationship between microdontia and chemotherapy. Regarding agenesis, when the third molar was excluded from the analysis, no direct correlation with treatment was observed. Still, no correlation was found between chemotherapy and changes in craniofacial growth or changes in tooth eruption. Finally, age at initiation of chemotherapy appears in most studies as the determining factor in dental alterations, with the state of dental formation being directly linked to the time of treatment. Conclusion: Chemotherapy treatment in children presents a risk factor for dental alterations, and the severity of these alterations is directly associated with the patient's age at the beginning of treatment, with the aforementioned alterations being more recurrent in patients who received chemotherapy between two and four years old.
Downloads
References
Feliciano SVM, Santos MdO, Pombo-de-Oliveira MS. Incidencia y mortalidad por Cáncer entre Niños e Adolescentes: una Revisión Narrativa. https://rbc.inca.gov.br/revista/index.php/revista 2021.
Alpaslan G, Alpaslan C, Gögen H, Aynur O, Çetiner S, Karadeniz C. Disturbances in oral and dental structures in patients with pediatric lymphoma after chemotherapyA preliminary report. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 1999;87(3):317-321.
Çetiner D, Çetiner S, Uraz A, Alpaslan GH, Alpaslan C, Memikoğlu TUT, Karadeniz C. Oral and dental alterations and growth disruption following chemotherapy in long-term survivors of childhood malignancies. Supportive Care in Cancer 2019;27(5):1891-1899.
Nanci A. Ten Cate histologia oral. Elsevier Editora Ltda.; 2019.
Avşar A, Elli M, Darka Ö, Pinarli G. Long-term effects of chemotherapy on caries formation, dental development, and salivary factors in childhood cancer survivors. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 2007;104(6):781-789.
Minicucci EM, Lopes LF, Crocci AJ. Dental abnormalities in children after chemotherapy treatment for acute lymphoid leukemia. Leukemia research 2003;27(1):45-50.
Ward E, DeSantis C, Robbins A, Kohler B, Jemal A. Childhood and adolescent cancer statistics, 2014. CA: a cancer journal for clinicians 2014;64(2):83-103.
Ishida Y, Sakamoto N, Kamibeppu K, Kakee N, Iwai T, Ozono S, Maeda N, Okamura J, Asami K, Inada H. Late effects and quality of life of childhood cancer survivors: Part 2. Impact of radiotherapy. International journal of hematology 2010;92(1):95-104.
Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer; 2004.
Näsman M, Forsberg C-M, Dahllöf G. Long-term dental development in children after treatment for malignant disease. European Journal of Orthodontics 1997;19(2):151-159.
Kaste SC, Goodman P, Leisenring W, Stovall M, Hayashi RJ, Yeazel M, Beiraghi S, Hudson MM, Sklar CA, Robison LL. Impact of radiation and chemotherapy on risk of dental abnormalities: a report from the Childhood Cancer Survivor Study. Cancer: Interdisciplinary International Journal of the American Cancer Society 2009;115(24):5817-5827.
Neville B, Damm D, Allen C, Chi A. Patologia Oral & Maxilofacial. Rio de Janeiro2016.
Proc P, Szczepańska J, Skiba A, Zubowska M, Fendler W, Młynarski W. Dental anomalies as late adverse effect among young children treated for cancer. Cancer research and treatment: official journal of Korean Cancer Association 2016;48(2):658.
SHAFER WG, HINE MK, LEVY BM. Tratado de Patologia Bucal. 4ª ed. Rio de Janeiro: Guanabara Koogan; 1987. p 02-79.
MCDONALD RE. Odontopediatria. 2ª ed. Rio de Janeiro: Guanabara Koogan; 1977. p 40-63.
Needleman HL, Allred E, Bellinger D, Leviton A, Rabinowitz M, Iverson K. Antecedents and correlates of hypoplastic enamel defects of primary incisors. Volume 14: Pediatric Dentistry; 1992.
Correa MSNP, Mathias RS. Radiologia em odontologia: primeira infância. Odontopediatria na primeira infância. São Paulo: Santos Publicações; 1998. p 209-219.
Jodlowska A, Postek-Stefanska L. Duration and dose of chemotherapy and dental development. Polônia: Dent Med Probl.; 2022.
Thesleff I, Jernvall J. The enamel knot: a putative signaling center regulating tooth development. 1997. Cold Spring Harbor Laboratory Press. p 257-267.
Duggal M. Root surface areas in long-term survivors of childhood cancer. Oral oncology 2003;39(2).
Oğuz A, Çetiner S, Karadeniz C, Alpaslan G, Alpaslan C, Pinarli G. Long‐term effects of chemotherapy on orodental structures in children with non‐Hodgkin's lymphoma. European journal of oral sciences 2004;112(1):8-11.
Kawakami T, Nakamura Y, Karibe H. Cyclophosphamide-induced morphological changes in dental root development of ICR mice. PloS one 2015;10(7):e0133256.
Khojastepour L, Zareifar S, Ebrahimi M. Dental anomalies and dental age assessment in treated children with acute lymphoblastic leukemia. Iranian journal of pediatric hematology and oncology 2014;4(4).
Wilberg P, Kanellopoulos A, Ruud E, Hjermstad M, Fosså S, Herlofson B. Dental abnormalities after chemotherapy in long-term survivors of childhood acute lymphoblastic leukemia 7-40 years after diagnosis. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2016;24(4).
Krasuska-Sławińska E, Dembowska-Bagińska B, Brożyna A, Olczak-Kowalczyk D, Czarnowska E, Sowińska A. Changes in the chemical composition of mineralised teeth in children after antineoplastic treatment. Contemp Oncol (Pozn); 2018.
Kinirons M, Fleming P, Boyd D. Dental caries experience of children in remission from acute lymphoblastic leukemia in relation to the duration of treatment and the period of time in remission Int J Paediatr Dent 1995.
Kaste S, Hopkins K, Jones D, Crom D, Greenwald C, Santana V. Dental abnormalities in children treated for acute lymphoblastic leukemia. Leukemia 1997;11(6):792-796.
Kang C-M, Hahn SM, Kim HS, Lyu CJ, Lee J-h, Lee J, Han JW. Clinical risk factors influencing dental developmental disturbances in childhood cancer survivors. Cancer Res Treat; 2018.
Pedersen L, Clausen N, Schroder H, Schmidt M, Poulsen S. Microdontia and hypodontia of premolars and permanent molars in childhood cancer survivors after chemotherapy. Int J Paediatr Dent; 2012.
Hölttä P, Alaluusua S, Saarinen-Pihkala U, Peltola J, Hovi L. Agenesis and microdontia of permanent teeth as late adverse effects after stem cell transplantation in young children. Cancer; 2005.
